ALX Oncology is a clinical-stage immuno-oncology company developing therapies that block the CD47 myeloid checkpoint mechanism exploited by cancer cells to evade the immune system. Our lead candidate, ALX148, is a fusion protein that comprises an engineered high affinity CD47 binding domain of SIRPα linked to an inactive Fc region of human immunoglobulin. ALX148 is designed to enhance the efficacy of antibody-based therapies and is in clinical development for a broad range of tumor types.
August 22, 2018 – ALX148 Blocks CD47 and Enhances Innate and Adaptive Antitumor Immunity with a Favorable Safety Profile Read article (PLOS ONE)
June 24, 2018 – VIDEO: ALX148 Clinical Program Overview By Sophia Randolph, MD, PhD, Chief Medical Officer at ALX Oncology View video (Healio)
June 22, 2018 – Alexo Therapeutics Changes Name to ALX Oncology