We’ve developed a new approach to CD47 blockade that is designed to maximize clinical activity and minimize toxicities

Our goal is to transform cancer treatment options for patients by developing evorpacept (ALX148) as a foundational checkpoint immunotherapy

Evorpacept Mechanism of Action

ALX Oncology was founded by a team of industry veterans to address fundamental challenges in blocking CD47 and to realize the full potential of this therapeutic target.

Cancer cells employ CD47, a cell surface protein, as a “don’t eat me” signal to evade detection by the immune system. ALX is developing a next-generation checkpoint inhibitor designed to have a high affinity for CD47 and to avoid the limitations caused by hematologic toxicities inherent in other CD47 blocking approaches. We believe our lead product candidate, evorpacept (ALX148), will have a wide therapeutic window to block the “don’t eat me” signal on cancer cells, and to leverage the immune activation of broadly used anti-cancer agents through combination strategies. Based on our clinical results to date in multiple oncology indications showing encouraging anti-tumor activity and tolerability, our strategy is to pursue evorpacept as a potentially critical component for future combination treatments in oncology.

Latest News updated at 00:33:09 UTC

Nov 11, 2021

ALX Oncology Reports Third Quarter 2021 Financial Results and Provides Clinical Development and Operational Highlights

Nov 09, 2021

ALX Oncology Announces Updated Data from Ongoing Clinical Trial (ASPEN-01) of Evorpacept Showing Emerging Clinical Benefit in Survival-Based Endpoints in Patients with Advanced Solid Tumors

Nov 04, 2021

ALX Oncology to Present New Evorpacept Clinical Data in Myelodysplastic Syndromes at 63rd ASH Annual Meeting

Twitter

ALX Oncology today reported financial results for the third quarter 2021 and provided clinical development and operational highlights: https://bit.ly/3Dkx8d6

ALX Oncology announced updated results from ASPEN-01, an ongoing evorpacept (ALX148) phase 1b study, evaluating patients with solid tumor malignancies at the @sitcancer 36th Anniversary Annual Meeting: https://bit.ly/3F0xoi1 #SITC21

ALX Oncology will present early clinical data from ASPEN-02, its ongoing Phase 1/2 study evaluating evorpacept (ALX148) in combination with azacitidine for the treatment of myelodysplastic syndromes, at the @ASH_hematology Annual Meeting: https://bit.ly/3mHaAxx #ASH21

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Our Technology

ALX Oncology’s fusion proteins are engineered to bind CD47 with significantly greater affinity than natural SIRPα. Our lead candidate, evorpacept, is an intravenously administered fusion protein containing two engineered high affinity CD47 binding domains of SIRPα linked to an inactive Fc region of human immunoglobulin.

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