
Pipeline
Our initial programs with ALX148 are focused on targeting CD47 across various oncology indications. Many forms of cancer use CD47 expression as a means of evading immune response. We are targeting the hematologic malignancies and solid tumor indications where we believe we have the greatest potential to address large unmet medical needs.
HNSCC
Head and Neck Squamous Cell Carcinoma
HNSCC
Head and Neck Squamous Cell Carcinoma
GC
Gastric/Gastroesophageal Junction Cancer
GC
Gastric/Gastroesophageal Junction Cancer
Breast Cancer
MDS
Myelodysplastic Syndromes
AML
Acute Myeloid Leukemia
NHL
Non-Hodgkin's Lymphoma
Clinical Trials
We plan to advance ALX148 for the treatment of MDS, a hematologic malignancy affecting over 70,000 people in the United States.
We also plan to develop ALX148 for the treatment of AML, a hematologic malignancy affecting over 40,000 people in the United States with nearly 20,000 newly diagnosed patients and over 11,000 deaths annually from the disease. Over half of patients are diagnosed at age 65 or older.
ALX148 has generated promising clinical data in solid tumors in combinations with a leading tumor antigen targeting antibody, a leading checkpoint inhibitor and chemotherapy.
We are investigating ALX148 for the first-line treatment of head and neck squamous cell carcinoma, or HNSCC. In the United States there are over 38,000 people living with metastatic HNSCC.
We are also investigating ALX148 for the second-line treatment of HER2-positive gastric/gastroesophageal junction, or GEJ, carcinoma. In the United States there are over 25,000 people living with metastatic gastric/GEJ carcinoma.
Information on Our Current Trials
Publications
- ALX148, a CD47 Blocker, in Combination with Rituximab in Patients with Relapsed/Refractory (R/R) Non-Hodgkin Lymphoma View poster (EHA 2020)
- A Phase 1 Study of ALX148, a CD47 Blocker, in Combination with Standard Anti Cancer Antibodies and Chemotherapy Regimens in Patients with Advanced Malignancy View poster (ASCO 2020)
ClinicalTrials.gov